Oral, clinical and medical microbiology

The ability to rapidly characterize and enumerate microorganisms is important in practically every field of Microbiology. Biosensors are changing this methodology. Antigen-antibody reactions can be mediated by staphylococcal Protein A. Since markers, including enzymes and fluorescent compounds, can be coupled to this protein, very sensitive assay systems are available ("ELISA," "Immunoblotting," etc.). Special media for rapid detection in mixed cultures is important. Ascorbic acid (vitamin C), inhibitory to several species of microorganisms is found in high concentrations in leukocytes. Scorbutic and normal leukocytes differ greatly in their ability to kill ingested bacteria. Iron compounds may play a role in these phenomena. Oral organisms may play a role in oral and other cancers via mutagen production.

SELECTED PUBLICATIONS:

Goldschmidt MC (2005) The use of biosensor and microarray techniques in
the rapid detection and identification of Salmonellae. J AOAC Int (in
press)

Warren DP, Goldschmidt MC, Thompson M, Keene H (2001) Survival of periodontiallly-related anaerobes on toothbrushes after 24 hours. J Amer Dent Assoc (in press)

Goldschmidt MC (2000) Biosensors (Review article). In: Encyclopedia of Food Microbiology, Academic Press London Vol.1 pp268-279.

Goldschmidt MC (1993) Biosensors: blessing or bane? J Rapid Method Autom Microbiol 2 (in press)

Goldschmidt MC (1993) The use of flow cytometry for the rapid characterization of monoclonal antibody production. J Rapid Method Autom Microbiol 1:273-285.

Goldschmidt MC (1991) Reduced bactericidal activity in neutrophils from scorbutic animals and the effect of ascorbic acid on these target bacteria in vivo and in vitro. Am J Clin Nutrit 54:1214S-1220S. [abstract]

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