Samuel Kaplan, Ph.D.
- Professor Emeritus
Department of Microbiology &
University of Texas-Houston Medical School
6431 Fannin Street, MSB 1.200
Houston, Texas 77030
Telephone: (713) 500-5502
Laboratory Telephone: (713) 500-7436
Ph.D., University of California-San Diego, 1963
Postdoctoral Fellow, MRC laboratories, Cambridge, UK
Role of oxygen and light in the regulation of gene expression and the nature of
genome complexity in microorganisms
In the laboratory of Professor Samuel Kaplan, the inducible intracytoplasmic membrane system of the bacterium Rhodobacter sphaeroides is employed as a model to study the role(s) of oxygen and light in the regulation of gene expression.
We are interested in:
- a molecular genetic analysis of cis and trans-acting genetic elements which respond to light and oxygen. The processing of these signals through electron transport chains, resulting in the control of gene expression.
- a determination of how the flux of cellular reductant through the various redox pools and terminal oxidases serves to regulate gene expression.
- the roles of assembly factors and redox intermediates in regulating the assembly of membrane complexes.
- the use of DNA chip technology to understand how redox-mediated signals serve to regulate global gene expression.
- Seok J-S, Kaplan S, and Oh J-I (2006) Interacting specificity of a histidine kinase and its cognate response regulator: the PrrBA system of Rhodobacter sphaeroides. Microbiol. 152:2479-2490. [abstract]
- Kim YJ, Ko IJ, Lee JM, Kang HY, Kim YM, Kaplan S, Oh JI (2007) Dominant role of the cbb3 oxidase in regulation of photosynthesis gene expression through the PrrBA system in Rhodobacter sphaeroides 2.4.1. J. Bacteriol. 189(15):5617-5625. [abstract]
- Mackenzie C, Eraso JM, Choudhary M, Roh JH, Zeng X, Bruscella P, Puskás Á, Kaplan S (2007) Postgenonic adventures with Rhodobacter sphaeroides Annu. Rev. Microbiol. 61:283-307. [abstract]
- Pan D, Hu D, Liu R, Zeng X, Kaplan S, Lu HP (2007) Fluctuating two-state light harvesting in a photosynthetic membrane. J. Phys. Chem. 111:8948-8956. [abstract]
- Hemp J, Han H, Roh JH, Kaplan S, Martinez TJ, Gennis RB (2007) Comparitive genomics and site-directed mutagenesis support the existence of only one input channel for protons in the C-family (cbb3 oxidase) of heme-copper oxygen reductases. Biochem. 46(35):9963-9972. [abstract]
- Moskvin OV, Kaplan S, Gilles-Gonzalez M-A, Gomelsky M (2007) Novel heme-based oxygen sensor with a revealing evolutionary history J. Biol. Chem. 282(39):28740-28748. [abstract]
- Zeng X, Roh JH, Callister SJ, Tavano CL, Donohue TJ, Lipton MS, Kaplan S (2007) Proteomic characterization of the Rhodobacter sphaeroides 2.4.1. photosynthetic membrane: identification of new proteins. J. Bacteriol. 189(20):7464-7474. [abstract]
- Arai H, Roh JH, Kaplan S (2007) Transcriptome dynamics during the transition from anaerobic photosynthesis to aerobic respiration in Rhodobacter sphaeroides 2.4.1. J. Bacteriol. In press. [abstract]
Location & Contact
6431 Fannin Street,
Houston, Texas 77030
P.O. Box 20708
Houston, Texas 77225
Our affiliates include the following:
- Departmental Faculty
- Theresa M. Koehler, Ph.D.
- Peter J. Christie, Ph.D.
- Nicholas De Lay, Ph.D.
- Jesus Eraso, Ph.D.
- Danielle Garsin, Ph.D.
- Heidi Kaplan, Ph.D.
- Samuel Kaplan, Ph.D.
- Nayun Kim, Ph.D.
- Ziyin Li, Ph.D.
- Jiqiang (Lanny) Ling, Ph.D.
- Michael C. Lorenz, Ph.D.
- Chris Mackenzie, Ph.D.
- William Margolin, Ph.D.
- Kevin A. Morano, Ph.D.
- Hung Ton-That, Ph.D.
- Ambro van Hoof, Ph.D.
- Departmental Faculty - Cross Appointees
- William Dowhan, Ph.D.
- Millicent Goldschmidt, Ph.D.
- Barrett Harvey, Ph.D.
- Jun Liu, Ph.D.
- Barbara E. Murray, M.D.
- Steven J. Norris, Ph.D.
- John L. Spudich, Ph.D.
- Adjunct Faculty
- Magnus Höök, Ph.D.
- Gregory S. May, Ph.D.
- Yi Xu, Ph.D.